Prenylflavonoids and prenyl/alkyl-phloroacetophenones: Synthesis and antitumour biological evaluation

Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2010-09, Vol.45 (9), p.4258-4269
Hauptverfasser:	Basabe, P., de Román, M., Marcos, I.S., Diez, D., Blanco, A., Bodero, O., Mollinedo, F., Sierra, B.G., Urones, J.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - chemical synthesis Acetophenones - chemistry Acetophenones - pharmacology Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumourals Biological and medical sciences C-Alkylation Cell Line, Tumor Cell Proliferation - drug effects Flavonoids Flavonoids - chemical synthesis Flavonoids - chemistry Flavonoids - pharmacology General aspects Humans Inhibitory Concentration 50 Medical sciences Pharmacology. Drug treatments Prenyl-phloroacetophenones Prenylflavonoids Spectrum Analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active. [Display omitted]
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2010.06.025