Total Synthesis of Chloptosin

Two is better that one: A new organocatalytic route for the asymmetric preparation of the embedded piperazic acids and a Stille coupling of an ortho‐chloropyrroloindole served as key steps in the total synthesis of the dimeric cyclopeptide chloptosin (see structure).

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-08, Vol.49 (35), p.6139-6142
Hauptverfasser:	Oelke, Alexander J, France, David J, Hofmann, Tatjana, Wuitschik, Georg, Ley, Steven V
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry antitumor agents Catalysis Dimerization organocatalysis peptides Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry piperazic acids Pyridazines - chemical synthesis Pyridazines - chemistry Stereoisomerism total synthesis
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Beschreibung
Zusammenfassung:	Two is better that one: A new organocatalytic route for the asymmetric preparation of the embedded piperazic acids and a Stille coupling of an ortho‐chloropyrroloindole served as key steps in the total synthesis of the dimeric cyclopeptide chloptosin (see structure).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201002880