Structures of New Erythrinan Alkaloids and Nitric Oxide Production Inhibitors from Erythrina crista-galli

Two new Erythrinan alkaloids, cristanines A and B (1, 2), were isolated from the bark of Erythrina crista-galli L. together with nine known Erythrinan alkaloids (3—5, 7—12) and an indole alkaloid (13). The structures of the compounds, cristanines A (1) and B (2), were elucidated by spectroscopic met...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2010/08/01, Vol.58(8), pp.1119-1122
Hauptverfasser:	Ozawa, Masaaki, Kawamata, Shunsuke, Etoh, Tadahiro, Hayashi, Masahiko, Komiyama, Kanki, Kishida, Akio, Kuroda, Chiaki, Ohsaki, Ayumi
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaloid Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Cell Line Cell Survival - drug effects Drug Evaluation, Preclinical Erythrina - chemistry Erythrina crista-galli Leguminosae Mice Molecular Structure Nitric Oxide - biosynthesis nitric oxide production inhibitor Plant Extracts - chemistry Plant Extracts - pharmacology Plant Stems - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	Two new Erythrinan alkaloids, cristanines A and B (1, 2), were isolated from the bark of Erythrina crista-galli L. together with nine known Erythrinan alkaloids (3—5, 7—12) and an indole alkaloid (13). The structures of the compounds, cristanines A (1) and B (2), were elucidated by spectroscopic methods. Three of the twelve compounds isolated showed significant inhibitory activity on lipopolysaccharide induced nitric oxide (NO) production.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.58.1119