HER2 Fragmentation and Breast Cancer Stratification

HER2 is a tyrosine kinase receptor whose overexpression in breast cancers correlates with poor prognosis. A subset of HER2-positive tumors also expresses a series of HER2 fragments, collectively known as p95HER2. These fragments are emerging as a valuable biomarker for this subset of patients, who h...

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Veröffentlicht in:	Clinical cancer research 2010-08, Vol.16 (16), p.4071-4073
Hauptverfasser:	ARRIBAS, Joaquin, PARRA-PALAU, Josep Lluís, PEDERSEN, Kim
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Biomarkers, Tumor - analysis Breast Neoplasms - genetics Breast Neoplasms - metabolism Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Peptide Fragments - analysis Pharmacology. Drug treatments Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Tumors
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Beschreibung
Zusammenfassung:	HER2 is a tyrosine kinase receptor whose overexpression in breast cancers correlates with poor prognosis. A subset of HER2-positive tumors also expresses a series of HER2 fragments, collectively known as p95HER2. These fragments are emerging as a valuable biomarker for this subset of patients, who have a particularly poor prognosis.
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-10-1501