Pericholecystic Rim Sign on PET/CT Secondary to Locally Invasive Gallbladder Carcinoma

A variety of gallbladder pathology (eg, carcinoma, acute and chronic cholecystitis, adenomyomatosis, cholestasis) has been imaged with F-18 fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography. The pericholecystic rim sign seen on conventional Tc-99m hepatobiliary scintigraphy is a marker of acute cholecystitis, possibly complicated by perforation or gangrene. A case of increased fluorodeoxyglucose uptake within the gallbladder fossa secondary to locally invasive gallbladder carcinoma reminiscent of a classic rim sign is presented.