Copper-Catalyzed Multicomponent Reaction: Synthesis of 4-Arylsulfonylimino-4,5-dihydrofuran Derivatives
A series of 4-arylsulfonylimino-4,5-dihydrofurans (14 examples) were efficiently synthesized in good to excellent yields by using the copper-catalyzed three-component reaction between sulfonyl azides, phenylacetylene, and β-ketoesters in tetrahydrofuran (THF) at 40 °C for 8 h in the presence of trie...
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Veröffentlicht in: | Journal of organic chemistry 2010-08, Vol.75 (16), p.5743-5745 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A series of 4-arylsulfonylimino-4,5-dihydrofurans (14 examples) were efficiently synthesized in good to excellent yields by using the copper-catalyzed three-component reaction between sulfonyl azides, phenylacetylene, and β-ketoesters in tetrahydrofuran (THF) at 40 °C for 8 h in the presence of triethylamine (TEA). A plausible mechanism for this process is proposed. |
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ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/jo1010075 |