15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90

15-Hydroxyeicosatetraenoic acid (15-HETE), generated by hypoxia, is a product of arachidonic acid and mainly catalyzed by 15-lipoxygenase (15-LO) in pulmonary artery. As HSP90 is known to be involved in apoptosis in other tissues and cells, we aim to test whether anti-apoptotic effect of 15-HETE is...

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Veröffentlicht in:	Life sciences (1973) 2010-08, Vol.87 (7), p.223-231
Hauptverfasser:	Zhang, Lei, Ma, Jun, Li, Yaqian, Guo, Lei, Ran, Yajuan, Liu, Shulin, Jiang, Chun, Zhu, Daling
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxyeicosatetraenoic acid Animals Apoptosis bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Caspases - genetics Caspases - metabolism Cell Hypoxia Cells, Cultured DNA Fragmentation Gene Expression Regulation Heat shock protein 90 HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Hydroxyeicosatetraenoic Acids - metabolism Hypoxia Male Mitochondria - metabolism Myocytes, Smooth Muscle - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Pulmonary Artery - cytology Rats Rats, Wistar
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