Pulling a Single Polymer Molecule off a Substrate Reveals the Binding Thermodynamics of Cosolutes

Pulling a Single Polymer Molecule off a Substrate Reveals the Binding Thermodynamics of Cosolutes

To bind or not to bind: Cosolutes modify, or even determine, the interactions between macromolecules and surfaces. A combination of single‐molecule atomic force microscopy with thermodynamic modeling allows the extraction of the binding parameters of cosolutes onto a macromolecule in solution and al...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2010-06, Vol.49 (28), p.4730-4733
Hauptverfasser: Geisler, Michael, Netz, Roland R, Hugel, Thorsten
Format: Artikel
Sprache:eng
Schlagworte:
adsorption
force spectroscopy
Glucose - chemistry
ligand effects
Models, Molecular
Molecular Conformation
Oxidation-Reduction
polymers
Polymers - chemistry
single-molecule studies
Thermodynamics
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Zusammenfassung:To bind or not to bind: Cosolutes modify, or even determine, the interactions between macromolecules and surfaces. A combination of single‐molecule atomic force microscopy with thermodynamic modeling allows the extraction of the binding parameters of cosolutes onto a macromolecule in solution and also in its surface‐adsorbed state.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200907098