Induction of sister chromatid exchanges by nicotinamide in Chinese hamster lung fibroblasts and human lymphoblastoid cells

Induction of sister chromatid exchanges by nicotinamide in Chinese hamster lung fibroblasts and human lymphoblastoid cells

Nicotinamide, which occurs naturally, produced sister chromatid exchanges in Chinese hamster lung fibroblasts and human lymphoblastoid cells. The inductions were dose-dependent with concentrations of 1.0–10.0 mM nicotinamide. Elastatinal, a protease inhibitor that has been reported to suppress induc...

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Veröffentlicht in:Biochemical and biophysical research communications 1979-10, Vol.90 (4), p.1147-1152
Hauptverfasser: Utakoji, Tadashi, Hosoda, Keiko, Umezawa, Kazuo, Sawamura, Mutsuko, Matsushima, Taijiro, Miwa, Masanao, Sugimura, Takashi
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Line
Cricetinae
Cricetulus
Crossing Over, Genetic - drug effects
Dose-Response Relationship, Drug
Humans
Lung
Lymphocytes
Niacinamide - pharmacology
Sister Chromatid Exchange - drug effects
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Zusammenfassung:Nicotinamide, which occurs naturally, produced sister chromatid exchanges in Chinese hamster lung fibroblasts and human lymphoblastoid cells. The inductions were dose-dependent with concentrations of 1.0–10.0 mM nicotinamide. Elastatinal, a protease inhibitor that has been reported to suppress induction of sister chromatid exchanges by N-methyl-N′-nitro-N-nitrosoguanidine, did not suppress induction of sister chromatid exchanges by nicotinamide in these cell lines.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(79)91156-2