Complement Fixation in Conventional and Regressing Virus-Induced Murine Leukemia

Immunization of Swiss mice with conventional strains of murine leukemia virus did not elicit an appreciable humoral complement fixation (CF) response. In contrast, CF antibody was observed in mice infected with a virus that induced a spontaneously regressing leukemia. After infection with regressing...

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Veröffentlicht in:	The Journal of immunology (1950) 1971-06, Vol.106 (6), p.1488-1492
Hauptverfasser:	Rich, Marvin A, Karl, Seung, Clymer, Rodney
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - analysis Antigen-Antibody Reactions Antigens Complement Fixation Tests Complement System Proteins Cross Reactions Friend murine leukemia virus Immune Sera Leukemia Virus, Murine - immunology Leukemia, Experimental - immunology Male Mice Organ Size Rabbits Remission, Spontaneous Spleen - pathology
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Zusammenfassung:	Immunization of Swiss mice with conventional strains of murine leukemia virus did not elicit an appreciable humoral complement fixation (CF) response. In contrast, CF antibody was observed in mice infected with a virus that induced a spontaneously regressing leukemia. After infection with regressing Friend virus, (RFV), CF antibody was present in mice in which leukemia had regressed but was absent in leukemic mice. CF antibody elicited by RFV cross-reacted with other strains of murine leukemia virus.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.106.6.1488