Barbiturates and calcium-activated adenosine triphosphatase

Barbiturates and calcium-activated adenosine triphosphatase

Anaesthetic barbiturates potentiate and convulsant barbiturates inhibit the calcium-activated adenosine triphosphatase (Ca-ATPase) activity in rat brain synaptosomes. Such differential effects and consequent modification of transmitter release may be important in the contrasting actions of these cla...

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Veröffentlicht in:Neuroscience letters 1979-10, Vol.14 (2), p.361-364
Hauptverfasser: Willow, M., Johnston, G.A.R.
Format: Artikel
Sprache:eng
Schlagworte:
Amobarbital - pharmacology
Animals
Barbiturates - pharmacology
Brain - drug effects
Brain - enzymology
Calcium-Transporting ATPases - metabolism
Pentobarbital - pharmacology
Phenobarbital - pharmacology
Rats
Synaptosomes - enzymology
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Zusammenfassung:Anaesthetic barbiturates potentiate and convulsant barbiturates inhibit the calcium-activated adenosine triphosphatase (Ca-ATPase) activity in rat brain synaptosomes. Such differential effects and consequent modification of transmitter release may be important in the contrasting actions of these classes of barbiturates in vivo.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(79)96175-5