Peripheral and central 5-hydroxytryptamine in trisomy 21

Peripheral and central metabolism of 5-hydroxytryptamine was studied in 16 patients with trisomy 21 and compared to that in 4 karyotypically normal mentally retarded children. Serum 5-hydroxytryptamine was markedly decreased in the trisomics whereas cerebrospinal fluid levels of 5-hydroxytryptamine...

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Veröffentlicht in:	Life sciences (1973) 1979-12, Vol.25 (23), p.2017-2022
Hauptverfasser:	Ternaux, J.P., Mattei, J.F., Faudon, M., Barrit, M.-C., Ardissone, J.P., Giraud, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Albumins - metabolism Child Down Syndrome - metabolism Fatty Acids, Nonesterified - metabolism Female Humans Hydroxyindoleacetic Acid - blood Hydroxyindoleacetic Acid - cerebrospinal fluid Male Proteins - metabolism Serotonin - blood Serotonin - cerebrospinal fluid Serotonin - metabolism
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Beschreibung
Zusammenfassung:	Peripheral and central metabolism of 5-hydroxytryptamine was studied in 16 patients with trisomy 21 and compared to that in 4 karyotypically normal mentally retarded children. Serum 5-hydroxytryptamine was markedly decreased in the trisomics whereas cerebrospinal fluid levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid were increased in the same groups. These results are discussed with respect to regulatory mechanisms of 5-HT metabolism.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(79)90606-4