Choroidal melanocytes — a model for studying the aging process in nonreplicative differentiated cells

Choroidal melanocytes — a model for studying the aging process in nonreplicative differentiated cells

Choroidal melanocytes differentiate and cease to divide early in postnatal life. They have characteristic organelles, the melanosomes, which are formed from tyrosine in a reaction catalyzed by tyrosinase. As animals become old, enzyme activity declines and the melanosomes show changes that are quant...

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Veröffentlicht in:Mechanisms of ageing and development 1979-11, Vol.11 (4), p.227-235
Hauptverfasser: Hu, Funan, Mah, Kunie
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Animals
Choroid - cytology
Choroid - ultrastructure
Haplorhini
Lipofuscin - analysis
Macaca mulatta
Melanocytes - ultrastructure
Microscopy, Fluorescence
Pigment Epithelium of Eye - ultrastructure
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Zusammenfassung:Choroidal melanocytes differentiate and cease to divide early in postnatal life. They have characteristic organelles, the melanosomes, which are formed from tyrosine in a reaction catalyzed by tyrosinase. As animals become old, enzyme activity declines and the melanosomes show changes that are quantitatively and qualitatively correlated to the animal's increasing age.
ISSN:0047-6374
1872-6216
DOI:10.1016/0047-6374(79)90002-2