4-N-AMINOACYLFORTIMICINS E

4-N-AMINOACYLFORTIMICINS E

The conversion of fortimicin E, a minor metabolite from the Micromonospora olivoasterospora fermentation which also produces fortimicin A and fortimicin B, to four 4-N-aminoacylfortimicins E was accomplished. The new 4-N-aminoacylfortimicins E showed only weak antimicrobial activity against several...

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Veröffentlicht in:Journal of antibiotics 1979, Vol.32(9), pp.884-890
Hauptverfasser: KURATH, PAUL, GRAMPOVNIK, DAVE, TADANIER, JACK, MARTIN, JERRY R., EGAN, RICHARD S., STANASZEK, RUTH S., CIROVIC, MOMIR, WASHBURN, WILLIAM H., HILL, PRESTON, DUNNIGAN, DANIEL A., LEONARD, JAMES E., JOHNSON, PAULETTE, GOLDSTEIN, ALMA W.
Format: Artikel
Sprache:eng
Schlagworte:
Aminoglycosides - chemical synthesis
Aminoglycosides - pharmacology
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Chemical Phenomena
Chemistry
Magnetic Resonance Spectroscopy
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Zusammenfassung:The conversion of fortimicin E, a minor metabolite from the Micromonospora olivoasterospora fermentation which also produces fortimicin A and fortimicin B, to four 4-N-aminoacylfortimicins E was accomplished. The new 4-N-aminoacylfortimicins E showed only weak antimicrobial activity against several Gram-negative and Gram-positive microorganisms.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.32.884