Clinical evaluation of dicumarinyl derivatives with a metabolic study of the radioactively labeled anticoagulants in animals

Clinical evaluation of dicumarinyl derivatives with a metabolic study of the radioactively labeled anticoagulants in animals

The common use of dicumarinyl derivatives for the treatment of thromboembolic diseases justifies further clinical evaluation of dicumarol and 4,4'-dihydroxydicumarinyl ethyl acetate [Pelentan, Tromexan, 3,3'-carboxymethylenebis (4-hydroxycoumarin) ethyl ester.] The need for a more thorough...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 1951-02, Vol.3 (2), p.171-181
Hauptverfasser: HAUSNER, E P, SHAFER, C L, CORSON, M, JOHNSON, O, TRUJILLO, T, LANGHAM, W
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anticoagulants
Blood Coagulation
Dicumarol
Ethyl Biscoumacetate
Old Medline
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Zusammenfassung:The common use of dicumarinyl derivatives for the treatment of thromboembolic diseases justifies further clinical evaluation of dicumarol and 4,4'-dihydroxydicumarinyl ethyl acetate [Pelentan, Tromexan, 3,3'-carboxymethylenebis (4-hydroxycoumarin) ethyl ester.] The need for a more thorough understanding of the pharmacodynamic action of dicumarinyl anticoagulants has prompted a study of their gross metabolism in animals, using C 14 -labeled materials.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.3.2.171