Inverse Changes of Serum Glucuronidase and Esterase of Breast Cancer Patients on Estrogen Therapy.

Summary Simultaneous sera glucuronidase, and esterase determinations have been carried out on the blood samples of 37 post-age 50 healthy control subjects (17 males and 20 females), 11 patients with advanced breast cancer and not on hormone therapy, and on 12 patients with advanced breast cancer receiving estrogen therapy. It was found that the control male subjects had both a higher serum glucuronidase and serum esterase than did the control female subjects. An inverse relationship was found for the changes in sera activity levels of glucuronidase and esterase in the patients with breast cancer subjected to variations in estrogen therapy.