Abnormal leukocyte electrophoretic mobility in myotonic dystrophy

Abnormal leukocyte electrophoretic mobility in myotonic dystrophy

Electrophoretic mobility of polymorphonuclear leukocytes (PMNs) was studied in 10 patients with myotonic dystrophy. The mobility of patients' PMNs differed significantly from that of controls. Following incubation with bacterial chemotactic factor the PMNs from patients showed significantly les...

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Veröffentlicht in:Journal of the neurological sciences 1979-12, Vol.44 (1), p.13-18
Hauptverfasser: Seay, Alan R., Ziter, Fred A., Hill, Harry R.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Cell Membrane
Chemotactic Factors - pharmacology
Child
Electrophoresis
Electrophysiology
Humans
Middle Aged
Myotonic Dystrophy - blood
Neutrophils - drug effects
Surface Properties
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Zusammenfassung:Electrophoretic mobility of polymorphonuclear leukocytes (PMNs) was studied in 10 patients with myotonic dystrophy. The mobility of patients' PMNs differed significantly from that of controls. Following incubation with bacterial chemotactic factor the PMNs from patients showed significantly less change in net surface charge compared to that in controls. Our data support a leukocyte membrane defect in myotonic dystrophy.
ISSN:0022-510X
DOI:10.1016/0022-510X(79)90219-3