Molecular Microanalysis of Pathological Specimens in situ with a Laser-Raman Microprobe

A laser-Raman microprobe has been used to identify microscopic inclusions of silicone polymer in standard paraffin sections of lymph node. This example of organic chemical microanalysis in situ in pathological tissue represents an extension of microanalytical capabilities from elemental analysis, pe...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1979-11, Vol.206 (4419), p.716-718
Hauptverfasser:	Abraham, Jerrold L., Etz, Edgar S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Electron Probe Microanalysis - methods Electrons Humans Laser spectroscopy Lasers Lesions Lymph nodes Lymph Nodes - analysis Microanalysis Neurons Pathology Raman scattering Silicone Elastomers - analysis Silicones Spectrum Analysis, Raman - methods
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creator	Abraham, Jerrold L. Etz, Edgar S.
description	A laser-Raman microprobe has been used to identify microscopic inclusions of silicone polymer in standard paraffin sections of lymph node. This example of organic chemical microanalysis in situ in pathological tissue represents an extension of microanalytical capabilities from elemental analysis, performed with electron and ion microprobes, to compound-specific molecular microanalysis.
doi_str_mv	10.1126/science.493979
format	Article
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This example of organic chemical microanalysis in situ in pathological tissue represents an extension of microanalytical capabilities from elemental analysis, performed with electron and ion microprobes, to compound-specific molecular microanalysis.</description><subject>Electron Probe Microanalysis - methods</subject><subject>Electrons</subject><subject>Humans</subject><subject>Laser spectroscopy</subject><subject>Lasers</subject><subject>Lesions</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - analysis</subject><subject>Microanalysis</subject><subject>Neurons</subject><subject>Pathology</subject><subject>Raman scattering</subject><subject>Silicone Elastomers - analysis</subject><subject>Silicones</subject><subject>Spectrum Analysis, Raman - methods</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkElPwzAQRi3EVgpXThx84pYyjrPYR1SxSa1ALOIYOc6YukriYidC_fcEpQKJ0xy-N29GHyHnDGaMxdlV0BZbjbNEcpnLPTJhINNIxsD3yQSAZ5GAPD0mJyGsAYZM8iNyONIT8r50Neq-Vp4urfZOtareBhuoM_RJdStXuw-rVU1fNqhtg22gtqXBdj39st2KKrpQAX30rBrVjoqNdyWekgOj6oBnuzklb7c3r_P7aPF49zC_XkSaJ9BFysScxRXLIAcsBWqeVlxkIq1Kkwo5MHHCJJZDBiIBRCNyqUpTGYjzVHM-JZejd7j62WPoisYGjXWtWnR9KPJEQMK4GMDZCA4fhuDRFBtvG-W3BYPip8hiV2QxVjMsXOzMfdlg9Yv_j9ehc_5PlicSspR_A5gyefs</recordid><startdate>19791109</startdate><enddate>19791109</enddate><creator>Abraham, Jerrold L.</creator><creator>Etz, Edgar S.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19791109</creationdate><title>Molecular Microanalysis of Pathological Specimens in situ with a Laser-Raman Microprobe</title><author>Abraham, Jerrold L. ; Etz, Edgar S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-af2312d16070eb8ec35d38685dbf5893402419ebeb80840eef879abfdf0275c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Electron Probe Microanalysis - methods</topic><topic>Electrons</topic><topic>Humans</topic><topic>Laser spectroscopy</topic><topic>Lasers</topic><topic>Lesions</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - analysis</topic><topic>Microanalysis</topic><topic>Neurons</topic><topic>Pathology</topic><topic>Raman scattering</topic><topic>Silicone Elastomers - analysis</topic><topic>Silicones</topic><topic>Spectrum Analysis, Raman - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abraham, Jerrold L.</creatorcontrib><creatorcontrib>Etz, Edgar S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abraham, Jerrold L.</au><au>Etz, Edgar S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Microanalysis of Pathological Specimens in situ with a Laser-Raman Microprobe</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1979-11-09</date><risdate>1979</risdate><volume>206</volume><issue>4419</issue><spage>716</spage><epage>718</epage><pages>716-718</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>A laser-Raman microprobe has been used to identify microscopic inclusions of silicone polymer in standard paraffin sections of lymph node. This example of organic chemical microanalysis in situ in pathological tissue represents an extension of microanalytical capabilities from elemental analysis, performed with electron and ion microprobes, to compound-specific molecular microanalysis.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>493979</pmid><doi>10.1126/science.493979</doi><tpages>3</tpages></addata></record>
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source	MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy
subjects	Electron Probe Microanalysis - methods Electrons Humans Laser spectroscopy Lasers Lesions Lymph nodes Lymph Nodes - analysis Microanalysis Neurons Pathology Raman scattering Silicone Elastomers - analysis Silicones Spectrum Analysis, Raman - methods
title	Molecular Microanalysis of Pathological Specimens in situ with a Laser-Raman Microprobe
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