Molecular Microanalysis of Pathological Specimens in situ with a Laser-Raman Microprobe

Molecular Microanalysis of Pathological Specimens in situ with a Laser-Raman Microprobe

A laser-Raman microprobe has been used to identify microscopic inclusions of silicone polymer in standard paraffin sections of lymph node. This example of organic chemical microanalysis in situ in pathological tissue represents an extension of microanalytical capabilities from elemental analysis, pe...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1979-11, Vol.206 (4419), p.716-718
Hauptverfasser: Abraham, Jerrold L., Etz, Edgar S.
Format: Artikel
Sprache:eng
Schlagworte:
Electron Probe Microanalysis - methods
Electrons
Humans
Laser spectroscopy
Lasers
Lesions
Lymph nodes
Lymph Nodes - analysis
Microanalysis
Neurons
Pathology
Raman scattering
Silicone Elastomers - analysis
Silicones
Spectrum Analysis, Raman - methods
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Beschreibung
Zusammenfassung:A laser-Raman microprobe has been used to identify microscopic inclusions of silicone polymer in standard paraffin sections of lymph node. This example of organic chemical microanalysis in situ in pathological tissue represents an extension of microanalytical capabilities from elemental analysis, performed with electron and ion microprobes, to compound-specific molecular microanalysis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.493979