Calcitonin: Inhibitory Effect on Eating in Rats

Calcitonin: Inhibitory Effect on Eating in Rats

Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feedin...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1979-11, Vol.206 (4420), p.850-852
Hauptverfasser: Freed, William J., Perlow, Mark J., Wyatt, Richard Jed
Format: Artikel
Sprache:eng
Schlagworte:
Administered dose
Animals
Body weight
Brain - drug effects
Calcitonin - administration & dosage
Calcitonin - pharmacology
Calcium
Depression, Chemical
Diuresis - drug effects
Dosage
Dose-Response Relationship, Drug
Eyes
Feeding Behavior - drug effects
Food
Injections, Intraventricular
Intravenous injections
Neurons
Rats
Subcutaneous injections
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Beschreibung
Zusammenfassung:Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.493987