Sequential study of C 1 q‐binding substances and of anti‐DNA antibodies in (NZB × NZW)F1 mice: Evidence for an acute phase of the lupus disease in 2‐month‐old mice

Longitudinal studies of C1 q and DNA‐binding substances were performed in sera from 38 (NZB × NZW)F1 female mice between days 39 and 150 of life. Results suggest a two‐phase evolution of circulating immune complexes and anti‐DNA antibodies in young (NZB × NZW)F1 mice and show the existence of an acu...

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Veröffentlicht in:	European journal of immunology 1979-08, Vol.9 (8), p.652-654
Hauptverfasser:	Fournié, Gilbert J., Minh, Marline Gayral‐Ta, Haas, Sylvie, Pourrat, Jacques P., Conte, Jean J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antibodies - immunology Antigen-Antibody Complex Binding Sites Complement C1 - immunology DNA - immunology Female Glomerulonephritis - complications Glomerulonephritis - immunology Lupus Vulgaris - complications Lupus Vulgaris - immunology Mice Mice, Inbred NZB Time Factors
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Beschreibung
Zusammenfassung:	Longitudinal studies of C1 q and DNA‐binding substances were performed in sera from 38 (NZB × NZW)F1 female mice between days 39 and 150 of life. Results suggest a two‐phase evolution of circulating immune complexes and anti‐DNA antibodies in young (NZB × NZW)F1 mice and show the existence of an acute phase of the disease during the second month of life of these mice.
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.1830090815