Subcutaneous implantation method for chronic glucocorticoid replacement therapy

Subcutaneous implantation method for chronic glucocorticoid replacement therapy

A procedure is described for replacing glucocorticoids by subcutaneous implantation of pellets formed from molten corticosterone and cholesterol. Hormone dose is controlled by varying the ratio of these two substances in the pellet. The method produces stable blood and brain corticosterone levels in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Physiology & behavior 1979-05, Vol.22 (5), p.867-870
Hauptverfasser: Meyer, Jerrold S., Micco, David J., Stephenson, Barbara Sue, Krey, Lewis C., McEwen, Bruce S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain Chemistry
Brain corticosterone
Cerebral Cortex - enzymology
Corticosterone - administration & dosage
Corticosterone - analysis
Corticosterone - pharmacology
Dexamethasone
Drug Implants
Glucocorticoid replacement
Glycerolphosphate Dehydrogenase - metabolism
Injections, Subcutaneous
Male
Radioimmunoassay
Rats
Serum corticosterone
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A procedure is described for replacing glucocorticoids by subcutaneous implantation of pellets formed from molten corticosterone and cholesterol. Hormone dose is controlled by varying the ratio of these two substances in the pellet. The method produces stable blood and brain corticosterone levels in the physiological range within 3 days and is shown to reinstate normal brain glycerolphosphate dehydrogenase activity in previously adrenalectomized rats. The procedure appears to be well-suited to long-term psycho- and neuro-endocrine studies.
ISSN:0031-9384
1873-507X
DOI:10.1016/0031-9384(79)90330-5