Effect of hypoxia on 67Ga incorporation into human granulocytes

Human granulocytes accumulate 67Ga when incubated under anoxic conditions and exclude the isotope when oxygenated. When incorporated, 67Ga is associated with the lysosomal fraction of the granulocytes. The ability of granulocytes to exclude the isotope except under hypoxic conditions may explain 67G...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1979-12, Vol.39 (12), p.4971-4974
Hauptverfasser:	Ostroy, F, Johnston, R B, Gams, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Gallium Radioisotopes Granulocytes - metabolism Humans Hypoxia In Vitro Techniques Inflammation - diagnostic imaging Lymphocytes - metabolism Neoplasms - diagnostic imaging Oxygen Radionuclide Imaging
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Zusammenfassung:	Human granulocytes accumulate 67Ga when incubated under anoxic conditions and exclude the isotope when oxygenated. When incorporated, 67Ga is associated with the lysosomal fraction of the granulocytes. The ability of granulocytes to exclude the isotope except under hypoxic conditions may explain 67Ga localization in abscesses and some tumor masses.
ISSN:	0008-5472