Jaundice during methyl testosterone therapy

1. 1. A syndrome of jaundice with distinctive features is described in association with methyl testosterone therapy. Seven cases are reported. 2. 2. The laboratory findings are characterized by a negative cephalin-flocculation reaction, only moderately elevated serum alkaline phosphatase and a markedly increased serum bilirubin. 3. 3. Liver biopsy suggests stasis of bile in the bile canaliculi and mild derangement of the contiguous cells. 4. 4. The role of methyl testosterone as the etiologic agent is discussed.