Effects of serial lateral hypothalamic destruction on feeding behavior, body weight, and neocortical and hippocampal EEG activity

A comparison was made of effects of simultaneous vs. serial lateral hypothalamic lesions on (i) feeding behavior, (ii) body weight, (iii) hippocampal rhythmical slow activity, (iv) neocortical low voltage fast activity, and (v) atropine-resistant patterns of neocortical and hippocampal EEG in rats. Serial lesions separated by 30 days produced no significant sparing of function on the first three variables but produced significant sparing on the last two. The results suggest the effects may be related to anatomic and/or pharmacologic differences in the way neural systems subserving the different functions are organized.