Effects of Exogenous Ubiquinone-10 on Endogenous Ubiquinone-10 in Canine Plasma and on Electron Transport Enzymes in Leucocytes

The distribution of exogenous ubiquinone-10 in canine plasma was examined using deuterium-labeled ubiquinone-10 in conjunction with a computerized gas chromatographmass spectrometry system. Electron transport enzymes in canine leucocytes were also studied. An increase in the plasma level of exogenous ubiquinone-10 did not affect the level of endogenous ubiquinone-10, and it was reflected in increased activities of the electron transport enzymes (succinate dehydrogenase Co Q reductase, succinate cytochrome c reductase and succinate oxidase) in leucocytes.