Infectious Bursal Disease Viral Infections. II. The Relationship of Age, Complement Levels, Virus-Neutralizing Antibody, Clotting, and Lesions

Experimental infection with infectious bursal disease virus (IBDV) reduced the complement (C) titer in 8-week-old chickens on days 3, 5, and 7 postinfection. Since the C titer was much lower in normal 2-week-old chickens than in normal 8-week-old chickens it could not be determined whether there was...

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Veröffentlicht in:Avian diseases 1979-01, Vol.23 (1), p.107-117
Hauptverfasser: Skeeles, J. K., Lukert, P. D., De Buysscher, E. V., Fletcher, O. J., Brown, J.
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Sprache:eng
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Zusammenfassung:Experimental infection with infectious bursal disease virus (IBDV) reduced the complement (C) titer in 8-week-old chickens on days 3, 5, and 7 postinfection. Since the C titer was much lower in normal 2-week-old chickens than in normal 8-week-old chickens it could not be determined whether there was a reduction in titer during the infection process. Virus-neutralizing antibody rose rapidly following infection in both 2- and 8-week-old chickens. Hyperimmune serum given during infection in an attempt to produce immune complexes did not increase disease severity in either 2- or 6-week-old susceptible chickens.
ISSN:0005-2086
1938-4351
DOI:10.2307/1589677