On the Intensity of the Accelerating Action of Eserine upon the Epinephrine Secretion of the Suprarenal Gland

Eserine was given intravenously or subcutaneously in etherized dog, whose suprarenal vein blood was taken by lumbar route or by the cava-pocket method. Epinephrine in the suprarenal vein blood was estimated by means of the rabbit intestine segment method. In the most of the experiments by the lumbar route preparation, in which the basal epinephrine secretion rate was not high, i. e. 0.01-0.03γ per kg. per minute from one gland, the rate of epinephrine secretion after eserine injection remained unaltered or accelerated. But the peak of the accelerated secretion was not high and was under 0.2γ. On the contrary, the action of eserine was enormous in the experiments of cava-pocket me-thod. In the latter cases, in which the basal secretion rate was 0.13-0.68 γ-per kg. per minute from both glands, the peak of the augmented epine-phrine secretion after eserine was 0.6-3.8γ. Further in the chronically splanchnicotomized dog non-effectiveness of eserine upon the-epinephrine secretion was observed. The action of eserine above quoted may be explainable, if we take the idea of chemical transmission of never impulses into consideration.