Distribution of Radioactive Silver Colloids in Tissues of Rodents Following Injection by Various Routes.

Summary 1. Intramuscular injection of a dextrin protected radio-silver colloid results in a high concentration of the injected material at the site of injection. 2. Intravenous injection of a dextrin-silver colloid into rats and intraperitoneal injection of a gelatin-silver colloid into mice result in deposition of the silver in highest concentration in the reticuloendothelial system. 3. Considerable silver was eliminated through the intestines and feces. The possible causes of such elimination under the conditions of this experiment are discussed. 4. A method of preparing tissues of small bulk for determining radio-silver activity with the Geiger-Muller counter is described.