Demonstration of dissimilar acute haemodynamic effects of ethanol and acetaldehyde

Demonstration of dissimilar acute haemodynamic effects of ethanol and acetaldehyde

To determine whether the acute cardiac depressant effects of ethanol could be attributed to its metabolite (acetaldehyde), either ethanol or acetaldehyde was intravenously infused into pentobarbital anaesthetised, closed-chest dogs. At a venous blood ethanol level of 199±43 (SE) mg·dl−1, ejection fr...

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Veröffentlicht in:Cardiovascular research 1979-08, Vol.13 (8), p.477-487
Hauptverfasser: FRIEDMAN, HOWARD S., MATSUZAKI, SHOHEI, CHOE, SOO-SANG, FERNANDO, HEMAL A., CELIS, ALVARO, ZAMAN, QAMAR, LIEBER, CHARLES S.
Format: Artikel
Sprache:eng
Schlagworte:
Acetaldehyde - blood
Acetaldehyde - pharmacology
Animals
Coronary Circulation - drug effects
Dogs
Ethanol - blood
Ethanol - pharmacology
Heart - drug effects
Hemodynamics - drug effects
Myocardium - metabolism
Oxygen Consumption - drug effects
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Zusammenfassung:To determine whether the acute cardiac depressant effects of ethanol could be attributed to its metabolite (acetaldehyde), either ethanol or acetaldehyde was intravenously infused into pentobarbital anaesthetised, closed-chest dogs. At a venous blood ethanol level of 199±43 (SE) mg·dl−1, ejection fraction had decreased from 35±2 to 30±2%, P
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/13.8.477