GABA metabolism in cultured glial cells

GABA metabolism in cultured glial cells

GABA-transaminase has been characterized in cultured astrocytes. It is identical to the synaptosomal and perikaryal enzyme in terms of charge, molecular weight, and stability, but it differs in its affinity for GABA, which is much higher in the glial compartment. GABA-transaminase has been shown to...

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Veröffentlicht in:Neurochemical research 1979-08, Vol.4 (4), p.517-527
Hauptverfasser: Bardakdjian, J, Tardy, M, Pimoule, C, Gonnard, P
Format: Artikel
Sprache:eng
Schlagworte:
4-Aminobutyrate Transaminase - metabolism
Animals
Astrocytes - metabolism
Cells, Cultured
gamma-Aminobutyric Acid - metabolism
gamma-Aminobutyric Acid - pharmacology
Glioma - enzymology
Mice
Synaptosomes - enzymology
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Zusammenfassung:GABA-transaminase has been characterized in cultured astrocytes. It is identical to the synaptosomal and perikaryal enzyme in terms of charge, molecular weight, and stability, but it differs in its affinity for GABA, which is much higher in the glial compartment. GABA-transaminase has been shown to be inducible by high GABA concentrations, which suggests that astrocytes have the possibility not only to transport GABA but also to metabolize the amino acid which is taken up.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00964645