Cytological changes in the pars distalis of the female rat hypophysis grafted under the kidney capsule

Intact female rats received transplants of two hypophysial partes distales under the kidney capsule. The plasma levels of prolactin were determined, and the ultrastructure of the grafted gland was studied 15, 45 and 90 days after the operation. Although prolactin levels in the three experimental gro...

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Veröffentlicht in:	Cell and tissue research 1979-07, Vol.199 (3), p.539-543
Hauptverfasser:	Aguado, L.I, Rodriguez, S, Bilbao, A, Rodriguez, E.M. (Universidad Austral de Chile, Valdivia (Chile). Instituto de Histologia y Patologia)
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endoplasmic Reticulum - ultrastructure Female Golgi Apparatus - ultrastructure Lymphocytes Pituitary Gland, Anterior - transplantation Pituitary Gland, Anterior - ultrastructure Prolactin - metabolism Rats Transplantation, Autologous
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Zusammenfassung:	Intact female rats received transplants of two hypophysial partes distales under the kidney capsule. The plasma levels of prolactin were determined, and the ultrastructure of the grafted gland was studied 15, 45 and 90 days after the operation. Although prolactin levels in the three experimental groups were significantly higher than those in control rats, a decrease in prolactin level was detected in the 45-day samples. Parallel ultrastructural changes suggest that between the 45th and 90th postoperative day a process is initiated leading to hyperplasia and hypertrophy of prolactotrophs.
ISSN:	0302-766X 1432-0878
DOI:	10.1007/BF00236089