Methylguanidine (MG) Movement of Serum and Urine in Chronic Renal Failure

Methylguanidine (MG) was determined by modifying the methods of Baker et al. and Menichini et al.. MG was measured by ion exchange column-chromatography using Dowex 50 W, and MG movement of serum and urine in uremia was examined. 1. According to the reduced renal function, viz, chronic renal failure, serum and urine MG levels increase, and it is probable that dialysis treatment is insufficient to remove MG from the body fluid. 2. When the ratio of MG to creatinine clearance is higher than 1. 0, patients are found to suffer from various symptoms of uremia and require dialysis treatment. 3. The daily urinary excretion of MG was found to be much higher immediately after a successful renal transplantation than in a single performance of hemodialysis. In such a case, uremic symptoms disappeared rapidly. Therefore, it is postulated that MG plays an important role in the symptoms of uremia.