Antipsychotic Drug Action in Schizophrenic Patients: Effect on Cortical Dopamine Metabolism After Long-Term Treatment

In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucle...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1979-09, Vol.205 (4413), p.1405-1407
Hauptverfasser:	Bacopoulos, N. C., Spokes, E. G., Bird, E. D., Roth, R. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Antipsychotic agents Antipsychotic Agents - therapeutic use Brain - metabolism Central nervous system Cerebral Cortex - metabolism Dopamine - metabolism Dopamine agents Dopamine receptors Homovanillic acid Homovanillic Acid - metabolism Humans Medical treatment Mental concentration Nucleus accumbens Nucleus Accumbens - metabolism Psychopharmacology Putamen Putamen - metabolism Schizophrenia Schizophrenia - drug therapy Schizophrenia - metabolism Statistical variance Time Factors
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Zusammenfassung:	In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucleus accumbens. The concentration of homovanillic acid was normal in the brains of schizophrenics who were not treated with antipsychotic drugs.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.38504