Chemoprophylactic Effectiveness of Aureomycin and Terramycin in Murine Bartonellosis.

Conclusions Both aureomycin and terramycin, started 48 to 72 hours before the expected onset of illness and continued for 9 days were found to be effective in preventing murine bartonellosis. Rats treated with these compounds developed no evidence of illness while the morbidity in the control groups was 100%, and the mortality 50 to 100%. A few bartonellae appeared in the blood of some of the treated rats, but anemia and hemoglobinuria were prevented. The chemoprophylactic effectiveness of these 2 compounds in murine bartonellosis is in contrast to negative results obtained with a wide variety of other antibiotics.