On the possible role of glutathione in maintaining human lens protein sulphydryls

On the possible role of glutathione in maintaining human lens protein sulphydryls

Glutathione can cleave the disulphide bonds in proteins from advanced nuclear cataractous lenses and in mixed disulphides of lens proteins and glutathione. The equilibrium constants for these reactions were estimated to be 0·02-0·05 and 0·07 respectively. Endogenous glutathione can protect lens prot...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Experimental eye research 1979-06, Vol.28 (6), p.665-671
1. Verfasser: Augusteyn, R.C.
Format: Artikel
Sprache:eng
Schlagworte:
Cataract - metabolism
Crystallins - metabolism
Disulfides - metabolism
glutathione
Glutathione - physiology
human lens protein sulphydryl
Humans
nuclear cataract
Sulfhydryl Compounds - metabolism
Time Factors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Glutathione can cleave the disulphide bonds in proteins from advanced nuclear cataractous lenses and in mixed disulphides of lens proteins and glutathione. The equilibrium constants for these reactions were estimated to be 0·02-0·05 and 0·07 respectively. Endogenous glutathione can protect lens protein sulphydryl groups from oxidation in vitro provided NADPH 2 and glucose-6-phosphate are added.
ISSN:0014-4835
1096-0007
DOI:10.1016/0014-4835(79)90067-8