Pharmacologic Effects in Man of a Potent, Long-Acting Dopamine Receptor Agonist

Pharmacologic Effects in Man of a Potent, Long-Acting Dopamine Receptor Agonist

Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 perce...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1979-09, Vol.205 (4411), p.1151-1153
Hauptverfasser: Lemberger, Louis, Crabtree, Ross E.
Format: Artikel
Sprache:eng
Schlagworte:
Administered dose
Adult
Amenorrhea
Blood plasma
Clinical Trials as Topic
Dopamine
Dopamine agonists
Dosage
Dose-Response Relationship, Drug
Drug receptors
Ergolines - pharmacology
Ergolines - therapeutic use
Humans
Informed Consent
Lactation disorders
Male
Medication administration
Medications
Mesylates
Middle Aged
Parkinsonism
Pharmaceutical research
Pharmacology
Placebos
Prolactin - blood
Receptors, Dopamine - drug effects
Testing
Time Factors
Volunteerism
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Beschreibung
Zusammenfassung:Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percent) and gradually return to control levels several days after drug administration is discontinued.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.382359