An improved synthesis of 18F-5-fluorouracil

An improved synthesis of 18F-5-fluorouracil

18F-F 2 produced by the 20 Ne(d, α) 18 F reaction was used to synthesize 25–35 mCi of 18F-5-fluorouracil. The mechanism of reaction of 18F-F 2 with uracil in acetic acid was studied by NMR and radiochemical techniques, and the primary reaction intermediate, 18F-5-fluoro-6-acetoxy-5,6-dihydrouracil,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The International journal of applied radiation and isotopes 1979-07, Vol.30 (7), p.401-405
Hauptverfasser: Vine, Elizabeth N., Young, David, Vine, William H., Wolf, Walter
Format: Artikel
Sprache:eng
Schlagworte:
Fluorine
Fluorouracil
Isotope Labeling - methods
Radioisotopes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:18F-F 2 produced by the 20 Ne(d, α) 18 F reaction was used to synthesize 25–35 mCi of 18F-5-fluorouracil. The mechanism of reaction of 18F-F 2 with uracil in acetic acid was studied by NMR and radiochemical techniques, and the primary reaction intermediate, 18F-5-fluoro-6-acetoxy-5,6-dihydrouracil, was isolated and identified. A novel fractional sublimation technique used in the synthesis and purification of 18F-5-fluorouracil is described.
ISSN:0020-708X
DOI:10.1016/0020-708X(79)90050-4