Cardiac output response to extreme hemodilution with hemoglobin solutions of various P50 values
Cardiovascular responses have been studied in baboons, after total exchange transfusion with hemoglobin solutions having various P50 values. At the end of the exchange transfusion, the hematocrit was 1.5%, the mean hemoglobin concentration was 4.4 g/dl, and the P50 varied between 12 and 26 mm Hg. Ca...
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| Veröffentlicht in: | Critical care medicine 1979-09, Vol.7 (9), p.380-384 |
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| container_title | Critical care medicine |
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| creator | ROSEN, ARTHUR L GOULD, STEVEN SEHGAL, LAKSHMAN R NOUD, GEORGE SEHGAL, HANSA L RICE, CHARLES L MOSS, GERALD S |
| description | Cardiovascular responses have been studied in baboons, after total exchange transfusion with hemoglobin solutions having various P50 values. At the end of the exchange transfusion, the hematocrit was 1.5%, the mean hemoglobin concentration was 4.4 g/dl, and the P50 varied between 12 and 26 mm Hg. Cardiac output did not change during the study, although heart rate increased, and stroke volume and MAP decreased. Hemoglobin concentration, per se, does not appear to be the critical stimulus for an increase in cardiac output with hemoglobin solution. In addition, the position of the hemoglobin-oxygen dissociation curve does not appear to influence these hemodynamic responses. The physiological response to anemia in the presence of hemoglobin solution appears different from that observed in the absence of plasma O2 carriers. |
| doi_str_mv | 10.1097/00003246-197909000-00006 |
| format | Article |
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At the end of the exchange transfusion, the hematocrit was 1.5%, the mean hemoglobin concentration was 4.4 g/dl, and the P50 varied between 12 and 26 mm Hg. Cardiac output did not change during the study, although heart rate increased, and stroke volume and MAP decreased. Hemoglobin concentration, per se, does not appear to be the critical stimulus for an increase in cardiac output with hemoglobin solution. In addition, the position of the hemoglobin-oxygen dissociation curve does not appear to influence these hemodynamic responses. The physiological response to anemia in the presence of hemoglobin solution appears different from that observed in the absence of plasma O2 carriers.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-197909000-00006</identifier><identifier>PMID: 111894</identifier><language>eng</language><publisher>United States: Williams & Wilkins</publisher><subject>Anemia - etiology ; Anemia - physiopathology ; Animals ; Cardiac Output ; Exchange Transfusion, Whole Blood ; Haplorhini ; Heart Rate ; Hematocrit ; Hemodilution ; Hemoglobins ; Male ; Oxygen - blood ; Oxyhemoglobins - metabolism ; Papio - physiology</subject><ispartof>Critical care medicine, 1979-09, Vol.7 (9), p.380-384</ispartof><rights>Williams & Wilkins 1979. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3546-55594c565dfe67b5ddbca589b295a75af9f0e2f70875bb2b27fa48d107221c603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/111894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROSEN, ARTHUR L</creatorcontrib><creatorcontrib>GOULD, STEVEN</creatorcontrib><creatorcontrib>SEHGAL, LAKSHMAN R</creatorcontrib><creatorcontrib>NOUD, GEORGE</creatorcontrib><creatorcontrib>SEHGAL, HANSA L</creatorcontrib><creatorcontrib>RICE, CHARLES L</creatorcontrib><creatorcontrib>MOSS, GERALD S</creatorcontrib><title>Cardiac output response to extreme hemodilution with hemoglobin solutions of various P50 values</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>Cardiovascular responses have been studied in baboons, after total exchange transfusion with hemoglobin solutions having various P50 values. At the end of the exchange transfusion, the hematocrit was 1.5%, the mean hemoglobin concentration was 4.4 g/dl, and the P50 varied between 12 and 26 mm Hg. Cardiac output did not change during the study, although heart rate increased, and stroke volume and MAP decreased. Hemoglobin concentration, per se, does not appear to be the critical stimulus for an increase in cardiac output with hemoglobin solution. In addition, the position of the hemoglobin-oxygen dissociation curve does not appear to influence these hemodynamic responses. The physiological response to anemia in the presence of hemoglobin solution appears different from that observed in the absence of plasma O2 carriers.</description><subject>Anemia - etiology</subject><subject>Anemia - physiopathology</subject><subject>Animals</subject><subject>Cardiac Output</subject><subject>Exchange Transfusion, Whole Blood</subject><subject>Haplorhini</subject><subject>Heart Rate</subject><subject>Hematocrit</subject><subject>Hemodilution</subject><subject>Hemoglobins</subject><subject>Male</subject><subject>Oxygen - blood</subject><subject>Oxyhemoglobins - metabolism</subject><subject>Papio - physiology</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UctOwzAQtBCvUvgDDj5xC_gRx_ERVbykSnCAs-UkGxJw6mI7FP4e0xY4sRfvzuzs2mOEMCXnlCh5QVJwlhcZVVIRlarsGyp20IQKngqm-C6akERlPFf8EB2F8EIIzYXkB2ifUlqqfIL0zPimNzV2Y1yOEXsIS7cIgKPD8BE9DIA7GFzT2zH2boFXfezWyLN1Vb_AwW2IgF2L343v3RjwgyAptyOEY7TXGhvgZHtO0dP11ePsNpvf39zNLudZzUV6hRBC5bUoRNNCISvRNFVtRKkqpoSRwrSqJcBaSUopqopVTLYmLxtKJGO0LgiforPN3KV3b2lv1EMfarDWLCDdSMu84IKULDWWm8bauxA8tHrp-8H4T02J_rZW_1irf61dQ0WSnm53jNUAzZ9w7WWi8w29cjaCD692XIHXHRgbO_3fh_EvH6GEsA</recordid><startdate>197909</startdate><enddate>197909</enddate><creator>ROSEN, ARTHUR L</creator><creator>GOULD, STEVEN</creator><creator>SEHGAL, LAKSHMAN R</creator><creator>NOUD, GEORGE</creator><creator>SEHGAL, HANSA L</creator><creator>RICE, CHARLES L</creator><creator>MOSS, GERALD S</creator><general>Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197909</creationdate><title>Cardiac output response to extreme hemodilution with hemoglobin solutions of various P50 values</title><author>ROSEN, ARTHUR L ; GOULD, STEVEN ; SEHGAL, LAKSHMAN R ; NOUD, GEORGE ; SEHGAL, HANSA L ; RICE, CHARLES L ; MOSS, GERALD S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3546-55594c565dfe67b5ddbca589b295a75af9f0e2f70875bb2b27fa48d107221c603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Anemia - etiology</topic><topic>Anemia - physiopathology</topic><topic>Animals</topic><topic>Cardiac Output</topic><topic>Exchange Transfusion, Whole Blood</topic><topic>Haplorhini</topic><topic>Heart Rate</topic><topic>Hematocrit</topic><topic>Hemodilution</topic><topic>Hemoglobins</topic><topic>Male</topic><topic>Oxygen - blood</topic><topic>Oxyhemoglobins - metabolism</topic><topic>Papio - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROSEN, ARTHUR L</creatorcontrib><creatorcontrib>GOULD, STEVEN</creatorcontrib><creatorcontrib>SEHGAL, LAKSHMAN R</creatorcontrib><creatorcontrib>NOUD, GEORGE</creatorcontrib><creatorcontrib>SEHGAL, HANSA L</creatorcontrib><creatorcontrib>RICE, CHARLES L</creatorcontrib><creatorcontrib>MOSS, GERALD S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROSEN, ARTHUR L</au><au>GOULD, STEVEN</au><au>SEHGAL, LAKSHMAN R</au><au>NOUD, GEORGE</au><au>SEHGAL, HANSA L</au><au>RICE, CHARLES L</au><au>MOSS, GERALD S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac output response to extreme hemodilution with hemoglobin solutions of various P50 values</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1979-09</date><risdate>1979</risdate><volume>7</volume><issue>9</issue><spage>380</spage><epage>384</epage><pages>380-384</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><abstract>Cardiovascular responses have been studied in baboons, after total exchange transfusion with hemoglobin solutions having various P50 values. 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| fulltext | fulltext |
| identifier | ISSN: 0090-3493 |
| ispartof | Critical care medicine, 1979-09, Vol.7 (9), p.380-384 |
| issn | 0090-3493 1530-0293 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anemia - etiology Anemia - physiopathology Animals Cardiac Output Exchange Transfusion, Whole Blood Haplorhini Heart Rate Hematocrit Hemodilution Hemoglobins Male Oxygen - blood Oxyhemoglobins - metabolism Papio - physiology |
| title | Cardiac output response to extreme hemodilution with hemoglobin solutions of various P50 values |
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