α-Melanocyte-Stimulating Hormone: Reduction in Adult Rat Brain After Monosodium Glutamate Treatment of Neonates

Intraperitoneal injection of monosodium glutamate in neonatal rats resulted in a 90 percent loss of α-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of α-melanocyte-s...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1979-08, Vol.205 (4408), p.827-829
Hauptverfasser:	Eskay, R. L., Brownstein, M. J., Long, R. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Arcuate nucleus Brain Brain - metabolism Cerebral cortex Endocrinology Glutamates - pharmacology Hormone research Hormones Hypothalamus Intraperitoneal injections Laboratory rats Melanocyte-Stimulating Hormones - metabolism Monosodium glutamate Physiological aspects Pituitary gland Primary literature Rats Rats as laboratory animals Sodium Glutamate - pharmacology Somatotropin
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Beschreibung
Zusammenfassung:	Intraperitoneal injection of monosodium glutamate in neonatal rats resulted in a 90 percent loss of α-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of α-melanocyte-stimulating hormone in the brain suggests that its primary source there is the neuronal perikarya of the arcuate nucleus.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.462194