Evaluation of a novel nanocrystalline hydroxyapatite paste Ostim registered in comparison to Alpha-BSM registered - more bone ingrowth inside the implanted material with Ostim registered compared to Alpha BSM registered

The purpose of this study was to evaluate the performance a newly developed nanocrystalline hydroxyapatite, OSTIM registered following functional implantation in femoral sites in thirty-eight sheep for 1, 2 or 3 months. Ostim registered 35 was compared to an established calcium phosphate, Alpha BSM registered . Biomechanical testing, mu -CT analysis, histological and histomorphological analyses were conducted to compare the treatments including evaluation of bone regeneration level, material degradation, implant biomechanical characteristics. The micro-computed tomography ( mu CT) analysis and macroscopic observations showed that Ostim registered seemed to diffuse easily particularly when the defects were created in a cancellous bone area. Alpha BSM registered remained in the defect. The performance of Ostim was good in terms of mechanical properties that were similar to Alpha BSM registered and the histological analysis showed that the bone regeneration was better with Ostim registered than with Alpha BSM registered . The histomorphometric analysis confirmed the qualitative analysis and showed more bone ingrowth inside the implanted material with Ostim registered when compared to Alpha BSM registered at all time points. The successful bone healing with osseous consolidation verifies the importance of the nanocrystalline hydroxyapatite in the treatment of metaphyseal osseous volume defects in the metaphyseal spongiosa.