Inhibition of Human Leukocyte Elastase by Brunsvicamides A-C: Cyanobacterial Cyclic Peptides

Cyanobacterial cyclic peptides, brunsvicamides A–C, were evaluated as inhibitors of human leukocyte elastase (HLE), and subsequently tested against a panel of proteases and two serine esterases. Brunsvicamides A–C were found to be highly selective for HLE.

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Bibliographische Detailangaben
Veröffentlicht in:	ChemMedChem 2009-09, Vol.4 (9), p.1425-1429
Hauptverfasser:	Sisay, Mihiret T., Hautmann, Stephanie, Mehner, Christian, König, Gabriele M., Bajorath, Jürgen, Gütschow, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Binding Sites brunsvicamides Computer Simulation Cyanobacteria - chemistry enzymes Humans inhibitors leukocyte elastase Leukocyte Elastase - antagonists & inhibitors Leukocyte Elastase - metabolism molecular modeling peptides Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - isolation & purification Serine Proteinase Inhibitors - pharmacology
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Beschreibung
Zusammenfassung:	Cyanobacterial cyclic peptides, brunsvicamides A–C, were evaluated as inhibitors of human leukocyte elastase (HLE), and subsequently tested against a panel of proteases and two serine esterases. Brunsvicamides A–C were found to be highly selective for HLE.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.200900139