Light Activation of Anti-CD3 in vivo Reduces the Growth of an Aggressive Ovarian Carcinoma

Light Activation of Anti-CD3 in vivo Reduces the Growth of an Aggressive Ovarian Carcinoma

A photoactivatable anti‐murine CD3 antibody was constructed. When reactivated in vivo in the presence of tumour pieces it markedly reduces the growth of ovarian carcinoma. Such antibodies provide a means to target T‐cells with a much higher degree of specificity to tumours, whilst minimising side ef...

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Veröffentlicht in:ChemMedChem 2007-11, Vol.2 (11), p.1591-1593
Hauptverfasser: Thompson, Stephen, Stewart, Robert, Smith, Jacqueline A., Self, Colin H.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
antibodies
Antibodies - immunology
caging
CD3 Complex - immunology
Cell Division - immunology
Female
Light
Mice
Ovarian Neoplasms - immunology
Ovarian Neoplasms - pathology
photoactivation
T-cells
tumour regression
UV light
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Zusammenfassung:A photoactivatable anti‐murine CD3 antibody was constructed. When reactivated in vivo in the presence of tumour pieces it markedly reduces the growth of ovarian carcinoma. Such antibodies provide a means to target T‐cells with a much higher degree of specificity to tumours, whilst minimising side effects in other non‐illuminated areas of the body.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200700116