Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis

Playing polo: Small-molecule inhibitors of polo-like kinase 1 are mostly ATP-competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small-molecule inhibitor of the protein-protein interactions required for Plk1 function.

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Bibliographische Detailangaben
Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2009-05, Vol.10 (7), p.1145-1148
Hauptverfasser:	Reindl, Wolfgang, Yuan, Juping, Krämer, Andrea, Strebhardt, Klaus, Berg, Thorsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Cycle Proteins - antagonists & inhibitors Cell Line, Tumor Centrosome enzymes HeLa Cells Heterocyclic Compounds, 2-Ring - chemistry Heterocyclic Compounds, 2-Ring - pharmacology Humans inhibitors Mitosis Polo-Like Kinase 1 polo‐like kinases Protein Binding Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Structure, Tertiary protein–protein interactions Proto-Oncogene Proteins - antagonists & inhibitors Small Molecule Libraries
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Beschreibung
Zusammenfassung:	Playing polo: Small-molecule inhibitors of polo-like kinase 1 are mostly ATP-competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small-molecule inhibitor of the protein-protein interactions required for Plk1 function.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.200900059