From meiosis to postmeiotic events: The secrets of histone disappearance

One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic differentiation, three major molecular mechanisms come t...

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Veröffentlicht in:	The FEBS journal 2010-02, Vol.277 (3), p.599-604
Hauptverfasser:	Gaucher, Jonathan, Reynoird, Nicolas, Montellier, Emilie, Boussouar, Fayçal, Rousseaux, Sophie, Khochbin, Saadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Cell division Cellular biology chromatin Chromatin - metabolism Chromosomal Proteins, Non-Histone - physiology epigenetics Genomics Histone Deacetylases - genetics histone variants Histones - metabolism Humans Male Meiosis - physiology Mice nucleosomes Nucleosomes - drug effects Nucleosomes - metabolism protamines Protamines - metabolism protease Proteases Proteins sperm Spermatids - metabolism Spermatogenesis - genetics spermatozoa transition proteins
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Beschreibung
Zusammenfassung:	One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic differentiation, three major molecular mechanisms come together to 'prepare' the nucleosomes for facilitated disassembly and histone removal.
ISSN:	1742-464X 1742-4658
DOI:	10.1111/j.1742-4658.2009.07504.x