Common Variations in 4p Locus are Related to Male Completed Suicide

Common Variations in 4p Locus are Related to Male Completed Suicide

Suicidal behavior is a multifactorial phenomenon, with a significant genetic predisposition. To assess the contribution of genes in the 4p region to suicide risk, we genotyped 36 single nucleotide polymorphisms from a 49Mb region on the chromosome arm 4p11-16 in a total of 288 male suicide victims a...

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Veröffentlicht in:Neuromolecular medicine 2009-03, Vol.11 (1), p.13-19
Hauptverfasser: Must, Anne, Kõks, Sulev, Vasar, Eero, Tasa, Gunnar, Lang, Aavo, Maron, Eduard, Väli, Marika
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biomedical and Life Sciences
Biomedicine
Chromosomes, Human, Pair 4 - genetics
Female
Genes
Genetic Markers
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Internal Medicine
Male
Middle Aged
Neurology
Neurosciences
Original Paper
Polymorphism, Genetic
Protein folding
Suicide
Suicides & suicide attempts
Young Adult
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Zusammenfassung:Suicidal behavior is a multifactorial phenomenon, with a significant genetic predisposition. To assess the contribution of genes in the 4p region to suicide risk, we genotyped 36 single nucleotide polymorphisms from a 49Mb region on the chromosome arm 4p11-16 in a total of 288 male suicide victims and 327 healthy male volunteers. The nonsynonymous variants rs1383180 in EVC gene, rs6811863 in TBC1D1 gene, rs362272 in HTT gene, and rs734312 in WFS1 gene were associated to the male completed suicide. However, only EVC polymorphism remained significant after correcting for multiple comparisons ( P  
ISSN:1535-1084
1559-1174
DOI:10.1007/s12017-008-8056-8