EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT

The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2‐deoxy‐2‐[18F]fluoro‐d‐glucose (FDG) using positron emission tomography/computed tomography (PET/CT). Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane,...

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Veröffentlicht in:Veterinary radiology & ultrasound 2010-03, Vol.51 (2), p.130-135
Hauptverfasser: LEE, MIN SU, KO, JEFF, LEE, AH RA, LEE, IN HYE, JUNG, MI AE, AUSTIN, BRENDA, CHUNG, HYUNWOO, NAHM, SANGSOEP, EOM, KIDONG
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container_end_page 135
container_issue 2
container_start_page 130
container_title Veterinary radiology & ultrasound
container_volume 51
creator LEE, MIN SU
KO, JEFF
LEE, AH RA
LEE, IN HYE
JUNG, MI AE
AUSTIN, BRENDA
CHUNG, HYUNWOO
NAHM, SANGSOEP
EOM, KIDONG
description The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2‐deoxy‐2‐[18F]fluoro‐d‐glucose (FDG) using positron emission tomography/computed tomography (PET/CT). Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane, (2) medetomidine/pentobarbital, (3) xylazine/ketamine, and (4) medetomidine/tiletamine–zolazepam in a randomized cross‐over design. The standard uptake value (SUV) of FDG was obtained in the frontal, parietal, temporal and occipital lobes, cerebellum, brainstem and whole brain, and compared within and between anesthetic protocols using the Friedman test with significance set at P
doi_str_mv 10.1111/j.1740-8261.2009.01636.x
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KO, JEFF ; LEE, AH RA ; LEE, IN HYE ; JUNG, MI AE ; AUSTIN, BRENDA ; CHUNG, HYUNWOO ; NAHM, SANGSOEP ; EOM, KIDONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2656-bc9a82e1bd66272d8b1253ed2d2f38e171451a50b3a2c6fc8661d5e387b9c4173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>18F-FDG</topic><topic>Adjuvants, Anesthesia</topic><topic>Adrenergic alpha-Agonists</topic><topic>anesthesia</topic><topic>Anesthetics, Combined</topic><topic>Anesthetics, Dissociative</topic><topic>Anesthetics, Inhalation</topic><topic>Anesthetics, Intravenous</topic><topic>Animals</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>brain glucose uptake</topic><topic>Cross-Over Studies</topic><topic>dog</topic><topic>Dogs - metabolism</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - administration &amp; dosage</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>Isoflurane</topic><topic>Ketamine</topic><topic>Male</topic><topic>Medetomidine</topic><topic>PET/CT</topic><topic>Positron-Emission Tomography - veterinary</topic><topic>Propofol</topic><topic>Radiopharmaceuticals - administration &amp; 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ultrasound</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEE, MIN SU</au><au>KO, JEFF</au><au>LEE, AH RA</au><au>LEE, IN HYE</au><au>JUNG, MI AE</au><au>AUSTIN, BRENDA</au><au>CHUNG, HYUNWOO</au><au>NAHM, SANGSOEP</au><au>EOM, KIDONG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT</atitle><jtitle>Veterinary radiology &amp; ultrasound</jtitle><addtitle>Vet Radiol Ultrasound</addtitle><date>2010-03</date><risdate>2010</risdate><volume>51</volume><issue>2</issue><spage>130</spage><epage>135</epage><pages>130-135</pages><issn>1058-8183</issn><eissn>1740-8261</eissn><abstract>The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2‐deoxy‐2‐[18F]fluoro‐d‐glucose (FDG) using positron emission tomography/computed tomography (PET/CT). Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane, (2) medetomidine/pentobarbital, (3) xylazine/ketamine, and (4) medetomidine/tiletamine–zolazepam in a randomized cross‐over design. The standard uptake value (SUV) of FDG was obtained in the frontal, parietal, temporal and occipital lobes, cerebellum, brainstem and whole brain, and compared within and between anesthetic protocols using the Friedman test with significance set at P&lt;0.05. Significant differences in SUVs were observed in various part of the brain associated with each anesthetic protocol. The SUV for the frontal and occipital lobes was significantly higher than in the brainstem in all dogs. Dogs receiving medetomidine/tiletamine–zolazepam also had significantly higher whole brain SUVs than the propofol/isoflurane group. We concluded that each anesthetic protocol exerted a different regional brain glucose uptake pattern. As a result, when comparing brain glucose uptake using PET/CT, one should consider the effects of anesthetic protocols on different regions of the glucose uptake in the dog's brain.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>20402395</pmid><doi>10.1111/j.1740-8261.2009.01636.x</doi><tpages>6</tpages></addata></record>
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source MEDLINE; Wiley-Blackwell Full Collection
subjects 18F-FDG
Adjuvants, Anesthesia
Adrenergic alpha-Agonists
anesthesia
Anesthetics, Combined
Anesthetics, Dissociative
Anesthetics, Inhalation
Anesthetics, Intravenous
Animals
Brain - diagnostic imaging
Brain - metabolism
brain glucose uptake
Cross-Over Studies
dog
Dogs - metabolism
Female
Fluorodeoxyglucose F18 - administration & dosage
Fluorodeoxyglucose F18 - pharmacokinetics
Isoflurane
Ketamine
Male
Medetomidine
PET/CT
Positron-Emission Tomography - veterinary
Propofol
Radiopharmaceuticals - administration & dosage
Radiopharmaceuticals - pharmacokinetics
SUV
Tiletamine
Tomography, X-Ray Computed
Xylazine
title EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT
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