EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT
The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2‐deoxy‐2‐[18F]fluoro‐d‐glucose (FDG) using positron emission tomography/computed tomography (PET/CT). Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane,...
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description | The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2‐deoxy‐2‐[18F]fluoro‐d‐glucose (FDG) using positron emission tomography/computed tomography (PET/CT). Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane, (2) medetomidine/pentobarbital, (3) xylazine/ketamine, and (4) medetomidine/tiletamine–zolazepam in a randomized cross‐over design. The standard uptake value (SUV) of FDG was obtained in the frontal, parietal, temporal and occipital lobes, cerebellum, brainstem and whole brain, and compared within and between anesthetic protocols using the Friedman test with significance set at P |
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Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane, (2) medetomidine/pentobarbital, (3) xylazine/ketamine, and (4) medetomidine/tiletamine–zolazepam in a randomized cross‐over design. The standard uptake value (SUV) of FDG was obtained in the frontal, parietal, temporal and occipital lobes, cerebellum, brainstem and whole brain, and compared within and between anesthetic protocols using the Friedman test with significance set at P<0.05. Significant differences in SUVs were observed in various part of the brain associated with each anesthetic protocol. The SUV for the frontal and occipital lobes was significantly higher than in the brainstem in all dogs. Dogs receiving medetomidine/tiletamine–zolazepam also had significantly higher whole brain SUVs than the propofol/isoflurane group. We concluded that each anesthetic protocol exerted a different regional brain glucose uptake pattern. As a result, when comparing brain glucose uptake using PET/CT, one should consider the effects of anesthetic protocols on different regions of the glucose uptake in the dog's brain.</description><identifier>ISSN: 1058-8183</identifier><identifier>EISSN: 1740-8261</identifier><identifier>DOI: 10.1111/j.1740-8261.2009.01636.x</identifier><identifier>PMID: 20402395</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>18F-FDG ; Adjuvants, Anesthesia ; Adrenergic alpha-Agonists ; anesthesia ; Anesthetics, Combined ; Anesthetics, Dissociative ; Anesthetics, Inhalation ; Anesthetics, Intravenous ; Animals ; Brain - diagnostic imaging ; Brain - metabolism ; brain glucose uptake ; Cross-Over Studies ; dog ; Dogs - metabolism ; Female ; Fluorodeoxyglucose F18 - administration & dosage ; Fluorodeoxyglucose F18 - pharmacokinetics ; Isoflurane ; Ketamine ; Male ; Medetomidine ; PET/CT ; Positron-Emission Tomography - veterinary ; Propofol ; Radiopharmaceuticals - administration & dosage ; Radiopharmaceuticals - pharmacokinetics ; SUV ; Tiletamine ; Tomography, X-Ray Computed ; Xylazine</subject><ispartof>Veterinary radiology & ultrasound, 2010-03, Vol.51 (2), p.130-135</ispartof><rights>2010 Veterinary Radiology & Ultrasound</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1740-8261.2009.01636.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1740-8261.2009.01636.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20402395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEE, MIN SU</creatorcontrib><creatorcontrib>KO, JEFF</creatorcontrib><creatorcontrib>LEE, AH RA</creatorcontrib><creatorcontrib>LEE, IN HYE</creatorcontrib><creatorcontrib>JUNG, MI AE</creatorcontrib><creatorcontrib>AUSTIN, BRENDA</creatorcontrib><creatorcontrib>CHUNG, HYUNWOO</creatorcontrib><creatorcontrib>NAHM, SANGSOEP</creatorcontrib><creatorcontrib>EOM, KIDONG</creatorcontrib><title>EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT</title><title>Veterinary radiology & ultrasound</title><addtitle>Vet Radiol Ultrasound</addtitle><description>The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2‐deoxy‐2‐[18F]fluoro‐d‐glucose (FDG) using positron emission tomography/computed tomography (PET/CT). 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As a result, when comparing brain glucose uptake using PET/CT, one should consider the effects of anesthetic protocols on different regions of the glucose uptake in the dog's brain.</description><subject>18F-FDG</subject><subject>Adjuvants, Anesthesia</subject><subject>Adrenergic alpha-Agonists</subject><subject>anesthesia</subject><subject>Anesthetics, Combined</subject><subject>Anesthetics, Dissociative</subject><subject>Anesthetics, Inhalation</subject><subject>Anesthetics, Intravenous</subject><subject>Animals</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>brain glucose uptake</subject><subject>Cross-Over Studies</subject><subject>dog</subject><subject>Dogs - metabolism</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - administration & dosage</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Isoflurane</subject><subject>Ketamine</subject><subject>Male</subject><subject>Medetomidine</subject><subject>PET/CT</subject><subject>Positron-Emission Tomography - veterinary</subject><subject>Propofol</subject><subject>Radiopharmaceuticals - administration & dosage</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>SUV</subject><subject>Tiletamine</subject><subject>Tomography, X-Ray Computed</subject><subject>Xylazine</subject><issn>1058-8183</issn><issn>1740-8261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkclOwzAQhi0EYn8F5BunBHscL7kgheCUQklKk4LgYmVxpZSWpaGivD0JhV6xRvJI8813mB8hTIlL23c2dan0iKNAUBcI8V1CBRPuagvtbwbbbU-4chRVbA8dNM2UEOAS5C7aA-IRYD7fR086inSYpTiJcBDrNLvSWT_Ew1GSJWEywEmM42R0GwxwGMT9WOOLUdCP8XiYBTe6W6IqcqLLHg7SVLd1iS8e8VBnZ2F2hHYm-ayxx7__IRpHOguvnEHS64fBwKlBcOEUpZ8rsLSohAAJlSoocGYrqGDClKWSepzmnBQsh1JMSiUErbhlShZ-6VHJDtHp2vu2eH1f2ubDzOumtLNZ_mJfl42RXueVxP-fZEz50mekJU9-yWUxt5V5W9TzfPFl_g7XAudr4LOe2a_NnBLTBWSmpsvBdDmYLiDzE5BZmfvR-KdtBc5aUDcfdrUR5ItnIyST3DzEPXN320uBAZhr9g2hk4iU</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>LEE, MIN SU</creator><creator>KO, JEFF</creator><creator>LEE, AH RA</creator><creator>LEE, IN HYE</creator><creator>JUNG, MI AE</creator><creator>AUSTIN, BRENDA</creator><creator>CHUNG, HYUNWOO</creator><creator>NAHM, SANGSOEP</creator><creator>EOM, KIDONG</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201003</creationdate><title>EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT</title><author>LEE, MIN SU ; KO, JEFF ; LEE, AH RA ; LEE, IN HYE ; JUNG, MI AE ; AUSTIN, BRENDA ; CHUNG, HYUNWOO ; NAHM, SANGSOEP ; EOM, KIDONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2656-bc9a82e1bd66272d8b1253ed2d2f38e171451a50b3a2c6fc8661d5e387b9c4173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>18F-FDG</topic><topic>Adjuvants, Anesthesia</topic><topic>Adrenergic alpha-Agonists</topic><topic>anesthesia</topic><topic>Anesthetics, Combined</topic><topic>Anesthetics, Dissociative</topic><topic>Anesthetics, Inhalation</topic><topic>Anesthetics, Intravenous</topic><topic>Animals</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>brain glucose uptake</topic><topic>Cross-Over Studies</topic><topic>dog</topic><topic>Dogs - metabolism</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - administration & dosage</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>Isoflurane</topic><topic>Ketamine</topic><topic>Male</topic><topic>Medetomidine</topic><topic>PET/CT</topic><topic>Positron-Emission Tomography - veterinary</topic><topic>Propofol</topic><topic>Radiopharmaceuticals - administration & dosage</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>SUV</topic><topic>Tiletamine</topic><topic>Tomography, X-Ray Computed</topic><topic>Xylazine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEE, MIN SU</creatorcontrib><creatorcontrib>KO, JEFF</creatorcontrib><creatorcontrib>LEE, AH RA</creatorcontrib><creatorcontrib>LEE, IN HYE</creatorcontrib><creatorcontrib>JUNG, MI AE</creatorcontrib><creatorcontrib>AUSTIN, BRENDA</creatorcontrib><creatorcontrib>CHUNG, HYUNWOO</creatorcontrib><creatorcontrib>NAHM, SANGSOEP</creatorcontrib><creatorcontrib>EOM, KIDONG</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Veterinary radiology & ultrasound</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEE, MIN SU</au><au>KO, JEFF</au><au>LEE, AH RA</au><au>LEE, IN HYE</au><au>JUNG, MI AE</au><au>AUSTIN, BRENDA</au><au>CHUNG, HYUNWOO</au><au>NAHM, SANGSOEP</au><au>EOM, KIDONG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT</atitle><jtitle>Veterinary radiology & ultrasound</jtitle><addtitle>Vet Radiol Ultrasound</addtitle><date>2010-03</date><risdate>2010</risdate><volume>51</volume><issue>2</issue><spage>130</spage><epage>135</epage><pages>130-135</pages><issn>1058-8183</issn><eissn>1740-8261</eissn><abstract>The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2‐deoxy‐2‐[18F]fluoro‐d‐glucose (FDG) using positron emission tomography/computed tomography (PET/CT). Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane, (2) medetomidine/pentobarbital, (3) xylazine/ketamine, and (4) medetomidine/tiletamine–zolazepam in a randomized cross‐over design. The standard uptake value (SUV) of FDG was obtained in the frontal, parietal, temporal and occipital lobes, cerebellum, brainstem and whole brain, and compared within and between anesthetic protocols using the Friedman test with significance set at P<0.05. Significant differences in SUVs were observed in various part of the brain associated with each anesthetic protocol. The SUV for the frontal and occipital lobes was significantly higher than in the brainstem in all dogs. Dogs receiving medetomidine/tiletamine–zolazepam also had significantly higher whole brain SUVs than the propofol/isoflurane group. We concluded that each anesthetic protocol exerted a different regional brain glucose uptake pattern. As a result, when comparing brain glucose uptake using PET/CT, one should consider the effects of anesthetic protocols on different regions of the glucose uptake in the dog's brain.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>20402395</pmid><doi>10.1111/j.1740-8261.2009.01636.x</doi><tpages>6</tpages></addata></record> |
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subjects | 18F-FDG Adjuvants, Anesthesia Adrenergic alpha-Agonists anesthesia Anesthetics, Combined Anesthetics, Dissociative Anesthetics, Inhalation Anesthetics, Intravenous Animals Brain - diagnostic imaging Brain - metabolism brain glucose uptake Cross-Over Studies dog Dogs - metabolism Female Fluorodeoxyglucose F18 - administration & dosage Fluorodeoxyglucose F18 - pharmacokinetics Isoflurane Ketamine Male Medetomidine PET/CT Positron-Emission Tomography - veterinary Propofol Radiopharmaceuticals - administration & dosage Radiopharmaceuticals - pharmacokinetics SUV Tiletamine Tomography, X-Ray Computed Xylazine |
title | EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT |
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