PTEN/mTOR and axon regeneration

How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic studies of axon growth during development and axon regeneration after injury reveal the PTEN dependent molecular mechanism as a commonality. This pathway could impact the processes occurring in the neuronal soma, su...

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Veröffentlicht in:	Experimental neurology 2010-05, Vol.223 (1), p.45-50
Hauptverfasser:	Park, Kevin K., Liu, Kai, Hu, Yang, Kanter, Jennifer L., He, Zhigang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axon Axons - metabolism CNS Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Models, Biological mTOR Nerve Regeneration - physiology Peripheral Nervous System Diseases - metabolism Peripheral Nervous System Diseases - physiopathology PNS Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Pten PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism regeneration Signal Transduction - physiology TOR Serine-Threonine Kinases
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Beschreibung
Zusammenfassung:	How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic studies of axon growth during development and axon regeneration after injury reveal the PTEN dependent molecular mechanism as a commonality. This pathway could impact the processes occurring in the neuronal soma, such as mTOR-regulated protein translation, and in the axons, such as cytoskeleton assembly. In this review, we will discuss the current understanding of the involvement of these processes in the regulation of axon growth and the potential implication in promoting axon regeneration after injury.
ISSN:	0014-4886 1090-2430
DOI:	10.1016/j.expneurol.2009.12.032