Hybrid modeling of penicillin fermentation process based on least square support vector machine

According to the problem of the pre-estimation with least square support vector machine (LSSVM) modeling is not ideal in the initial stages of penicillin fermentation process, two hybrid models are designed by utilizing the advantage of LSSVM and kinetics model. Through selecting the appropriate state variables and adopting these methods for penicillin fermentation, the mycelial concentration can be pre-estimated. Experiment results show that these hybrid modeling methods not only improve the above problem, but also have higher predicting accuracy and more powerful generalization ability than the single LSSVM method.