A novel d-glucose derivative radiolabeled with technetium-99m: Synthesis, biodistribution studies and scintigraphic images in an experimental model of Ehrlich tumor

A d-glucose analogue was synthesized; its biodistribution studies and scintigraphic imagens were performed. A d-glucose-MAG 3 derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-04, Vol.20 (8), p.2478-2480
Hauptverfasser:	de Barros, André Luís Branco, Cardoso, Valbert Nascimento, Mota, Luciene das Graças, Leite, Elaine Amaral, de Oliveira, Mônica Cristina, Alves, Ricardo José
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - pathology Contrast media. Radiopharmaceuticals d-glucose Diagnosis agents Glucose - chemical synthesis Glucose - chemistry Glucose - pharmacokinetics MAG 3 Medical sciences Mice Organotechnetium Compounds - chemistry Pharmacology. Drug treatments Technetium-99m Tissue Distribution Tumor
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Zusammenfassung:	A d-glucose analogue was synthesized; its biodistribution studies and scintigraphic imagens were performed. A d-glucose-MAG 3 derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio. Thus, d-glucose-MAG 3 could be considered as agent for tumor diagnosis.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2010.03.003